Overexpressed BSR1-Mediated Enhancement of Disease Resistance Depends on the MAMP-Recognition System.
Identifieur interne : 000094 ( Main/Exploration ); précédent : 000093; suivant : 000095Overexpressed BSR1-Mediated Enhancement of Disease Resistance Depends on the MAMP-Recognition System.
Auteurs : Yasukazu Kanda [Japon] ; Yoko Nishizawa [Japon] ; Takashi Kamakura [Japon] ; Masaki Mori [Japon]Source :
- International journal of molecular sciences [ 1422-0067 ] ; 2020.
Abstract
Plant plasma membrane-localized receptors recognize microbe-associated molecular patterns (MAMPs) and activate immune responses via various signaling pathways. Receptor-like cytoplasmic kinases (RLCKs) are considered key signaling factors in plant immunity. BROAD-SPECTRUM RESISTANCE 1 (BSR1), a rice RLCK, plays a significant role in disease resistance. Overexpression of BSR1 confers strong resistance against fungal and bacterial pathogens. Our recent study revealed that MAMP-triggered immune responses are mediated by BSR1 in wild-type rice and are hyperactivated in BSR1-overexpressing rice. It was suggested that hyperactivated immune responses were responsible for the enhancement of broad-spectrum disease resistance; however, this remained to be experimentally validated. In this study, we verified the above hypothesis by disrupting the MAMP-recognition system in BSR1-overexpressing rice. To this end, we knocked out OsCERK1, which encodes a well-characterized MAMP-receptor-like protein kinase. In the background of BSR1 overaccumulation, the knockout of OsCERK1 nearly abolished the enhancement of blast resistance. This finding indicates that overexpressed BSR1-mediated enhancement of disease resistance depends on the MAMP-triggered immune system, corroborating our previously suggested model.
DOI: 10.3390/ijms21155397
PubMed: 32751339
PubMed Central: PMC7432911
Affiliations:
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sortKey="Kanda, Yasukazu" sort="Kanda, Yasukazu" uniqKey="Kanda Y" first="Yasukazu" last="Kanda">Yasukazu Kanda</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602</wicri:regionArea><wicri:noRegion>Tsukuba 305-8602</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510</wicri:regionArea><wicri:noRegion>Noda 278-8510</wicri:noRegion></affiliation></author><author><name sortKey="Nishizawa, Yoko" sort="Nishizawa, Yoko" uniqKey="Nishizawa Y" first="Yoko" last="Nishizawa">Yoko Nishizawa</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602</wicri:regionArea><wicri:noRegion>Tsukuba 305-8602</wicri:noRegion></affiliation></author><author><name sortKey="Kamakura, Takashi" sort="Kamakura, Takashi" uniqKey="Kamakura T" first="Takashi" last="Kamakura">Takashi Kamakura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510</wicri:regionArea><wicri:noRegion>Noda 278-8510</wicri:noRegion></affiliation></author><author><name sortKey="Mori, Masaki" sort="Mori, Masaki" uniqKey="Mori M" first="Masaki" last="Mori">Masaki Mori</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602</wicri:regionArea><wicri:noRegion>Tsukuba 305-8602</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510</wicri:regionArea><wicri:noRegion>Noda 278-8510</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of molecular sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plant plasma membrane-localized receptors recognize microbe-associated molecular patterns (MAMPs) and activate immune responses via various signaling pathways. Receptor-like cytoplasmic kinases (RLCKs) are considered key signaling factors in plant immunity. BROAD-SPECTRUM RESISTANCE 1 (BSR1), a rice RLCK, plays a significant role in disease resistance. Overexpression of <i>BSR1</i> confers strong resistance against fungal and bacterial pathogens. Our recent study revealed that MAMP-triggered immune responses are mediated by BSR1 in wild-type rice and are hyperactivated in <i>BSR1</i>-overexpressing rice. It was suggested that hyperactivated immune responses were responsible for the enhancement of broad-spectrum disease resistance; however, this remained to be experimentally validated. In this study, we verified the above hypothesis by disrupting the MAMP-recognition system in BSR1-overexpressing rice. To this end, we knocked out <i>OsCERK1</i>, which encodes a well-characterized MAMP-receptor-like protein kinase. In the background of BSR1 overaccumulation, the knockout of <i>OsCERK1</i> nearly abolished the enhancement of blast resistance. This finding indicates that overexpressed <i>BSR1</i>-mediated enhancement of disease resistance depends on the MAMP-triggered immune system, corroborating our previously suggested model.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32751339</PMID><DateRevised><Year>2020</Year><Month>08</Month><Day>29</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1422-0067</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>15</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>29</Day></PubDate></JournalIssue><Title>International journal of molecular sciences</Title><ISOAbbreviation>Int J Mol Sci</ISOAbbreviation></Journal><ArticleTitle>Overexpressed <i>BSR1</i>-Mediated Enhancement of Disease Resistance Depends on the MAMP-Recognition System.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E5397</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/ijms21155397</ELocationID><Abstract><AbstractText>Plant plasma membrane-localized receptors recognize microbe-associated molecular patterns (MAMPs) and activate immune responses via various signaling pathways. Receptor-like cytoplasmic kinases (RLCKs) are considered key signaling factors in plant immunity. BROAD-SPECTRUM RESISTANCE 1 (BSR1), a rice RLCK, plays a significant role in disease resistance. Overexpression of <i>BSR1</i> confers strong resistance against fungal and bacterial pathogens. Our recent study revealed that MAMP-triggered immune responses are mediated by BSR1 in wild-type rice and are hyperactivated in <i>BSR1</i>-overexpressing rice. It was suggested that hyperactivated immune responses were responsible for the enhancement of broad-spectrum disease resistance; however, this remained to be experimentally validated. In this study, we verified the above hypothesis by disrupting the MAMP-recognition system in BSR1-overexpressing rice. To this end, we knocked out <i>OsCERK1</i>, which encodes a well-characterized MAMP-receptor-like protein kinase. In the background of BSR1 overaccumulation, the knockout of <i>OsCERK1</i> nearly abolished the enhancement of blast resistance. This finding indicates that overexpressed <i>BSR1</i>-mediated enhancement of disease resistance depends on the MAMP-triggered immune system, corroborating our previously suggested model.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kanda</LastName><ForeName>Yasukazu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nishizawa</LastName><ForeName>Yoko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamakura</LastName><ForeName>Takashi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mori</LastName><ForeName>Masaki</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-8093-8848</Identifier><AffiliationInfo><Affiliation>Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>JP20H02953</GrantID><Agency>JSPS KAKENHI</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType 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Yasukazu" sort="Kanda, Yasukazu" uniqKey="Kanda Y" first="Yasukazu" last="Kanda">Yasukazu Kanda</name></noRegion><name sortKey="Kamakura, Takashi" sort="Kamakura, Takashi" uniqKey="Kamakura T" first="Takashi" last="Kamakura">Takashi Kamakura</name><name sortKey="Kanda, Yasukazu" sort="Kanda, Yasukazu" uniqKey="Kanda Y" first="Yasukazu" last="Kanda">Yasukazu Kanda</name><name sortKey="Mori, Masaki" sort="Mori, Masaki" uniqKey="Mori M" first="Masaki" last="Mori">Masaki Mori</name><name sortKey="Mori, Masaki" sort="Mori, Masaki" uniqKey="Mori M" first="Masaki" last="Mori">Masaki Mori</name><name sortKey="Nishizawa, Yoko" sort="Nishizawa, Yoko" uniqKey="Nishizawa Y" first="Yoko" last="Nishizawa">Yoko Nishizawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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